This hieroglyphic was on what seemed to be an altar in the underground temple that is Smokey’s lair.
The snake-like creature on the left is probably Smokey itself. The creature on the right, whose hand is outstretched with an offer of something (food?) for Smokey, looks a lot like the jackal-headed Egyptian god Anubis:
Anubis was the god who protected the dead and brought them to the afterlife. That certainly fits in with the world of LOST, with all its undead characters wandering around.
There’s been a big debate, among LOST fans, about whether the four-toed statue is meant to be Anubis or the goddess Taweret. I’d thought it was Taweret, based on the similarities of the headdresses, the toes, and Taweret’s mission of protecting pregnant women. The appearance of the Anubis hieroglyphic, though, in such a prominent place in Smokey’s lair, suggests that even if the statue is Taweret, Anubis must also play an important role in the history of the Island.
Editing to add: Answers people have given for “Other” in the poll are “It’s not offering, it’s welcoming,” “The Golden Apple of Discordia,” “Tootsie roll pop… ‘how many licks does it take’,” “Nothing – the hand is just outstreched towards the monster,” “Blessings,” “Nothing,” “A heart,” and “A heart to be weighed (judged).” Good answers!